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Abstract #1004

3D joint T1/T1ρ mapping and water-fat imaging for contrast-agent free myocardial tissue characterization

Michael G Crabb1, Karl P Kunze1,2, Carlos Velasco1, Anastasia Fotaki1, Camila Munoz1, Alina Hua1, Radhouene Neji1,2, Claudia Prieto1, and Rene M Botnar1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom


In patients with suspected myocardial infarction, late-gadolinium enhancement (LGE) images are often acquired to detect focal and diffuse scarring. T1ρ is a sensitive marker for assessment of macromolecular-water interaction and has shown potential for non-contrast enhanced imaging of fibrosis. Here we propose a novel free-breathing, 3D whole-heart joint T1/T1ρ mapping sequence with Dixon encoding to provide 3D T1 and T1ρ maps and co-registered water and fat volumes with isotropic resolution for comprehensive contrast-agent free myocardial tissue characterization. Preliminary 3D joint T1/T1ρ mapping and water/fat imaging results demonstrate good agreement in phantoms and promising results in-vivo in healthy volunteers and patients.

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