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Abstract #1004

3D joint T1/T1ρ mapping and water-fat imaging for contrast-agent free myocardial tissue characterization

Michael G Crabb1, Karl P Kunze1,2, Carlos Velasco1, Anastasia Fotaki1, Camila Munoz1, Alina Hua1, Radhouene Neji1,2, Claudia Prieto1, and Rene M Botnar1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom

Synopsis

In patients with suspected myocardial infarction, late-gadolinium enhancement (LGE) images are often acquired to detect focal and diffuse scarring. T1ρ is a sensitive marker for assessment of macromolecular-water interaction and has shown potential for non-contrast enhanced imaging of fibrosis. Here we propose a novel free-breathing, 3D whole-heart joint T1/T1ρ mapping sequence with Dixon encoding to provide 3D T1 and T1ρ maps and co-registered water and fat volumes with isotropic resolution for comprehensive contrast-agent free myocardial tissue characterization. Preliminary 3D joint T1/T1ρ mapping and water/fat imaging results demonstrate good agreement in phantoms and promising results in-vivo in healthy volunteers and patients.

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Keywords