Association between lesion locations and depressive symptoms in acute stroke patients using voxel-based lesion-symptom mapping
Peng Wang1, Jinjing Wang2, Yong Zhang3, Mengmeng Gu4, Shiyi Jiang1, Dawei Yin1, Wen Sun1, and Xinfeng Liu2
1The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, 2Jinling Hospital, Nanjing, China, 3GE Healthcare, Shanghai, China, 4Nanjing First Hospital, Nanjing, China
Post-stroke depression (PSD) is a common neuropsychiatric symptom after stroke. The purpose of this study was to investigate the association between lesion locations of brain stroke and PSD occurrence using Voxel-based Lesion-Symptom Mapping (VLSM). VLSM analysis identified clusters within anterior cingulate gyrus, left hippocampus, left lingual lobe where lesions were significantly associated with PSD. The lesion location showed the promise to be used as an independent risk factor of PSD in patients with acute ischemic stroke.
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