Abstract #1017

Association between lesion locations and depressive symptoms in acute stroke patients using voxel-based lesion-symptom mapping

Peng Wang¹, Jinjing Wang², Yong Zhang³, Mengmeng Gu⁴, Shiyi Jiang¹, Dawei Yin¹, Wen Sun¹, and Xinfeng Liu²

¹The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, ²Jinling Hospital, Nanjing, China, ³GE Healthcare, Shanghai, China, ⁴Nanjing First Hospital, Nanjing, China

Synopsis

Post-stroke depression (PSD) is a common neuropsychiatric symptom after stroke. The purpose of this study was to investigate the association between lesion locations of brain stroke and PSD occurrence using Voxel-based Lesion-Symptom Mapping (VLSM). VLSM analysis identified clusters within anterior cingulate gyrus, left hippocampus, left lingual lobe where lesions were significantly associated with PSD. The lesion location showed the promise to be used as an independent risk factor of PSD in patients with acute ischemic stroke.

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