Post-stroke depression (PSD) is a common neuropsychiatric symptom after stroke. The purpose of this study was to investigate the association between lesion locations of brain stroke and PSD occurrence using Voxel-based Lesion-Symptom Mapping (VLSM). VLSM analysis identified clusters within anterior cingulate gyrus, left hippocampus, left lingual lobe where lesions were significantly associated with PSD. The lesion location showed the promise to be used as an independent risk factor of PSD in patients with acute ischemic stroke.
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