Meeting Banner
Abstract #1019

Contraction-Induced Changes in Acetylcarnitine in the Human Vastus Lateralis Muscle Detected by 1H MRS at 3T

Rajakumar Nagarajan1, Christopher Hayden2, Samantha Gilmore2, and Jane A Kent2
1Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, United States, 2Kinesiology, University of Massachusetts Amherst, Amherst, MA, United States


Using 1H-MRS at 3T, vastus lateralis muscle acetylcarnitine was measured in 8 young male subjects at rest and in response to incremental, dynamic knee extension contractions. Intramyocellular [acetylcarnitine] increased >3-fold in response to the contraction protocol, thus buffering mitochondrial acetyl coenzyme A and thereby supporting oxidative metabolism of glucose and fat in the citric acid cycle. Measurement of acetylcarnitine has the potential to be a useful tool for the investigation of muscle substrate use and metabolic flexibility. This work is the first demonstration of dynamic changes in muscle [acetylcarnitine] at 3T.

This abstract and the presentation materials are available to members only; a login is required.

Join Here