Assessment of skeletal muscle energy metabolism by 31P MRS in COVID19 and Multiple Sclerosis patients: technical and clinical insights
Antoine Naëgel1,2, Jabrane Karkouri1,2,3, Hélène Ratiney1, Djahid Kennouche1,4, Nicolas Royer1,4, Guillaume Millet1,4, Jill Slide5, Jérôme Morel6, Pierre Croisille1, and Magalie Viallon1
1Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, 2Siemens Healthineers, Saint-Denis, France, 3Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, 4LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité,Université Jean Monnet Saint Etienne, Université Claude Bernard Lyon 1, Université Savoie Mont Blanc, Saint-Etienne, France, 5Department of Radiology, Michigan State University, East Lansing, MI, United States, 6anaesthetics and intensive care department, UJM-Saint-Etienne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Etienne, France
Dynamic 31P MRS was performed during a standardized exercise of the lower leg, in patients with chronic fatigue enrolled in 2 clinical studies: multiple sclerosis patients and COVID19 patients that were hospitalized in intensive care unit and requiring respiratory assistance. In this work, we also revisit certain assumptions on the metabolite T1 and question shortcuts often made to shorten 31P protocol for a better patient’s compliance.
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