Abstract #1021

Assessment of skeletal muscle energy metabolism by 31P MRS in COVID19 and Multiple Sclerosis patients: technical and clinical insights

Antoine Naëgel^1,2, Jabrane Karkouri^1,2,3, Hélène Ratiney¹, Djahid Kennouche^1,4, Nicolas Royer^1,4, Guillaume Millet^1,4, Jill Slide⁵, Jérôme Morel⁶, Pierre Croisille¹, and Magalie Viallon¹

¹Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, ²Siemens Healthineers, Saint-Denis, France, ³Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, ⁴LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité,Université Jean Monnet Saint Etienne, Université Claude Bernard Lyon 1, Université Savoie Mont Blanc, Saint-Etienne, France, ⁵Department of Radiology, Michigan State University, East Lansing, MI, United States, ⁶anaesthetics and intensive care department, UJM-Saint-Etienne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Etienne, France

Synopsis

Dynamic 31P MRS was performed during a standardized exercise of the lower leg, in patients with chronic fatigue enrolled in 2 clinical studies: multiple sclerosis patients and COVID19 patients that were hospitalized in intensive care unit and requiring respiratory assistance. In this work, we also revisit certain assumptions on the metabolite T1 and question shortcuts often made to shorten 31P protocol for a better patient’s compliance.

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