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Abstract #1025

Assessment of skeletal muscle extracellular volume fraction in Becker Muscular Dystrophy using MR fingerprinting with water and fat separation

Benjamin Marty1,2, Pierre-Yves Baudin1,2, Yves Fromes1,2, Karim Wahbi3, and Harmen Reyngoudt1,2
1NMR Laboratory, Institute of Myology, Neuromuscular Investigation Center, Paris, France, 2NMR Laboratory, CEA, DRF, IBFJ, MIRCen, Paris, France, 3Reference Center for Muscle Diseases Paris-Est, Institute of Myology, Paris, France


Becker muscular dystrophy (BMD) is a genetic neuromuscular disorder leading to muscle weakness and degeneration. Quantitative MRI has been widely proposed to characterize skeletal muscle tissue structure of BMD and revealed increased intramuscular fat fraction associated with functional decline. In this study, we measured the extracellular volume fraction (ECV) of skeletal muscle tissues using MR fingerprinting with water and fat separation. We evaluated this variable as an early imaging biomarker of skeletal muscle tissue alterations. Compared to healthy controls, we showed that the muscles of BMD subjects present elevated ECV before fatty replacement occurs.

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