Sarcopenia is commonly associated with ageing, whereby individuals lose muscle mass and strength. One potential contributor to sarcopenia is the degeneration of motor units (MU), defined as a single motor neuron and the muscle fibres it innervates. We used motor unit MRI (MUMRI) to investigate changes to spontaneous MU activity and morphology in a cohort of healthy ageing adults. We found that MU activity and morphology did not appear to change with healthy ageing. We next aim to apply the MUMRI technique in patients with sarcopenia to look for evidence of accelerated MU loss compared to these healthy controls.
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