With upcoming therapeutic developments, quantitative MR is increasingly used to assess disease state and progression in neuromuscular disorders, including SMA. Yet, little is known about the disease state in the arm muscles in SMA. A multi-modal MR approach was used to examine fat fraction (FF), T2-relaxation time and diffusion properties, in the arm muscles of SMA patients and controls. Our results showed higher FF in the arm muscles of SMA patients which were negatively associated with the level of muscle strength. No clear changes were observed for qT2 while diffusion indices showed potential for mapping changes in muscle tissue itself.
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