Multi-modal MR in the upper arm muscles of patients with Spinal Muscular Atrophy
Melissa Tamara Hooijmans1, Laura E. Habets2, Sandra A.M. van den Berg-Faay1, Martijn Froeling3, Gustav J. Strijkers4, Fay-lynn Asselman5, Aart J. Nederveen1, Jeroen A.L Jeneson2, Bart Bartels2, and W. Ludo van der Pol5
1Department of Radiology and Nuclear Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Center, Amsterdam, Netherlands, 2Center for Child Development, Exercise and Physical Literacy, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Biomedical Engineering & Physics, Amsterdam Movement Sciences, Amsterdam University Medical Center, Amsterdam, Netherlands, 5Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands
With upcoming therapeutic developments, quantitative MR is increasingly used to assess disease state and progression in neuromuscular disorders, including SMA. Yet, little is known about the disease state in the arm muscles in SMA. A multi-modal MR approach was used to examine fat fraction (FF), T2-relaxation time and diffusion properties, in the arm muscles of SMA patients and controls. Our results showed higher FF in the arm muscles of SMA patients which were negatively associated with the level of muscle strength. No clear changes were observed for qT2 while diffusion indices showed potential for mapping changes in muscle tissue itself.
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