Imaging of hyperpolarized (HP) 13C magnetization is typically done using direct detection of the 13C signal. However, indirect 1H-based detection via J-coupled protons has the advantage of reducing gradient requirements and enhancing sensitivity, as well as practical advantages. We have developed an INEPT-based EPI sequence, which we tested by acquiring 3D images of a 13C formate phantom after transfer of thermal polarization from 1H to 13C. We also tested a novel deconvolution method to correct ghosting artifacts introduced in EPI images by J-coupling. These methods will be translated into in vivo HP imaging experiments in the next phase of research.
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