Meeting Banner
Abstract #1038

3D EPI sequence for indirect detection of hyperpolarized [2-13C]lactate with J-coupling artifact correction

Tyler Blazey1 and Cornelius von Morze1
1Washington University in St. Louis, St. Louis, MO, United States


Imaging of hyperpolarized (HP) 13C magnetization is typically done using direct detection of the 13C signal. However, indirect 1H-based detection via J-coupled protons has the advantage of reducing gradient requirements and enhancing sensitivity, as well as practical advantages. We have developed an INEPT-based EPI sequence, which we tested by acquiring 3D images of a 13C formate phantom after transfer of thermal polarization from 1H to 13C. We also tested a novel deconvolution method to correct ghosting artifacts introduced in EPI images by J-coupling. These methods will be translated into in vivo HP imaging experiments in the next phase of research.

This abstract and the presentation materials are available to members only; a login is required.

Join Here