SLOW-EPSI for the Whole Brain Detection of Phosphorylethanolamine (PE) at 7T
Guodong Weng1,2, Piotr Radojewski1,2, Philippe Schucht3, Roland Wiest1,2, and Johannes Slotboom1,2
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), INSEL Gruppe AG, University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland, 3Department of Neurosurgery, Inselspital Bern and University Hospital, Bern, Switzerland
Purpose: to detect phosphoethanolamine (PEtn or PE) in vivo for whole-brain MRSI, overcoming challenges of B1+-inhomogeneities and CSDE at 7T.
Methods: An EPSI-based B1+ robust SLOW-editing was applied to three healthy subjects. TE = 90 ms, TR = 1500 ms, and TA = 9:04 mins.
Results: the editing PE signal at 3.22 ppm was clearly present, and the B1+-homogenous result/map was obtained.
Conclusions: whole-brain in vivo PE-editing can be performed in around 9 minutes measurement time and is therefore clinically applicable.
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