Abstract #1042

SLOW-EPSI for the Whole Brain Detection of Phosphorylethanolamine (PE) at 7T

Guodong Weng^1,2, Piotr Radojewski^1,2, Philippe Schucht³, Roland Wiest^1,2, and Johannes Slotboom^1,2

¹Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), INSEL Gruppe AG, University of Bern, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ³Department of Neurosurgery, Inselspital Bern and University Hospital, Bern, Switzerland

Synopsis

Purpose: to detect phosphoethanolamine (PEtn or PE) in vivo for whole-brain MRSI, overcoming challenges of B₁⁺-inhomogeneities and CSDE at 7T.

Methods: An EPSI-based B₁⁺ robust SLOW-editing was applied to three healthy subjects. TE = 90 ms, TR = 1500 ms, and TA = 9:04 mins.

Results: the editing PE signal at 3.22 ppm was clearly present, and the B₁⁺-homogenous result/map was obtained.

Conclusions: whole-brain in vivo PE-editing can be performed in around 9 minutes measurement time and is therefore clinically applicable.

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