Abstract #1086

New Endo Coil and Novel Methods for Improving mpMR-TRUS Guided Fusion Prostate Biopsies with Hyperpolarized C-13 Pyruvate Molecular Imaging

Daniel Tewelde Gebrezgiabbhier^1,2, Hsin-Yu Chen³, Robert Bok³, Lucas Carvajal³, Matthew Cooperberg², Hao Nguyen², Katsuto Shinohara², Kimberly Okamoto³, Mary Frost³, Zhen Wang³, Michael Ohliger³, Jeremy Gordon³, Peder Larson³, Rahul Aggarwal², and Daniel Vigneron³

¹Bioengineering, University of California, San Francisco, CA, United States, ²School of Medicine, University of California, San Francisco, CA, United States, ³Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States

Synopsis

A new ¹³C/¹H endorectal coil was designed, 3D printed, and manufactured with optimal dimensions to improve the comfort and tolerability for patients and provide higher SNR over the original endorectal coil used for over a decade. After bench and phantom tests, the new endorectal coil was applied in patient studies for mpMRI-TRUS guided fusion prostate biopsies with hyperpolarized C-13 pyruvate molecular imaging in three patients on active surveillance. The results of this novel approach with the new ¹³C/¹H coil provides an increase in sensitivity, image quality and ultimately supports better detection of lesions.

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