New Endo Coil and Novel Methods for Improving mpMR-TRUS Guided Fusion Prostate Biopsies with Hyperpolarized C-13 Pyruvate Molecular Imaging
Daniel Tewelde Gebrezgiabbhier1,2, Hsin-Yu Chen3, Robert Bok3, Lucas Carvajal3, Matthew Cooperberg2, Hao Nguyen2, Katsuto Shinohara2, Kimberly Okamoto3, Mary Frost3, Zhen Wang3, Michael Ohliger3, Jeremy Gordon3, Peder Larson3, Rahul Aggarwal2, and Daniel Vigneron3
1Bioengineering, University of California, San Francisco, CA, United States, 2School of Medicine, University of California, San Francisco, CA, United States, 3Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States
A new 13C/1H endorectal coil was designed, 3D printed, and manufactured with optimal dimensions to improve the comfort and tolerability for patients and provide higher SNR over the original endorectal coil used for over a decade. After bench and phantom tests, the new endorectal coil was applied in patient studies for mpMRI-TRUS guided fusion prostate biopsies with hyperpolarized C-13 pyruvate molecular imaging in three patients on active surveillance. The results of this novel approach with the new 13C/1H coil provides an increase in sensitivity, image quality and ultimately supports better detection of lesions.
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