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Abstract #1088

Robust Fiducial-based Registration for Mechatronics-Assisted MRI-guided Focal Laser Ablation of Localized Prostate Cancer

Eric Knull1,2, Claire Park2,3, Jeffrey Bax2, David Tessier2, and Aaron Fenster1,2,3
1Biomedical Engineering, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada, 3Medical Biophysics, Western University, London, ON, Canada


MRI-guided focal laser ablation (FLA) is a promising minimally-invasive therapy method for men with localized prostate cancer. We previously developed an MR-compatible mechatronic system capable of transperineal needle delivery within an in-bore 3T MRI environment. This work presents an improved multi-fiducial structure for robust registration of the mechatronic system for MRI-guided FLA needle delivery. Real-time MRI-guided needle delivery was performed in a tissue-mimicking prostate phantom to virtual targets simulating focal ablation zones. With the implementation of the improved multi-fiducial structure, mechatronics-assisted MRI-guided needle delivery enables a 1.44 mm ablation radius, showing potential utility for accurate FLA to small prostate lesions.

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