Abstract #1088

Robust Fiducial-based Registration for Mechatronics-Assisted MRI-guided Focal Laser Ablation of Localized Prostate Cancer

Eric Knull^1,2, Claire Park^2,3, Jeffrey Bax², David Tessier², and Aaron Fenster^1,2,3

¹Biomedical Engineering, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Medical Biophysics, Western University, London, ON, Canada

Synopsis

MRI-guided focal laser ablation (FLA) is a promising minimally-invasive therapy method for men with localized prostate cancer. We previously developed an MR-compatible mechatronic system capable of transperineal needle delivery within an in-bore 3T MRI environment. This work presents an improved multi-fiducial structure for robust registration of the mechatronic system for MRI-guided FLA needle delivery. Real-time MRI-guided needle delivery was performed in a tissue-mimicking prostate phantom to virtual targets simulating focal ablation zones. With the implementation of the improved multi-fiducial structure, mechatronics-assisted MRI-guided needle delivery enables a 1.44 mm ablation radius, showing potential utility for accurate FLA to small prostate lesions.

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