Abstract #1137

Effect of Resistance Training on Lower-Extremity Gait Kinematics and Muscle Morphology

Michael Ko¹, Andrew Schmidt¹, Elka Rubin¹, Lauren Watkins², Marco Barbieri¹, Laurel Hales³, Anthony Gatti¹, Garry Gold^1,2, Feliks Kogan¹, Scott Delp^2,4,5, Valentina Mazzoli¹, and Akshay Chaudhari^1,6

¹Radiology, Stanford University, Stanford, CA, United States, ²Bioengineering, Stanford University, Stanford, CA, United States, ³Electrical Engineering, Stanford University, Stanford, CA, United States, ⁴Mechanical Engineering, Stanford University, Stanford, CA, United States, ⁵Orthopaedic Surgery, Stanford University, Stanford, CA, United States, ⁶Biomedical Data Science, Stanford University, Stanford, CA, United States

Synopsis

Gait retraining has been studied as an intervention to improve osteoarthritis symptoms but has a variety of limitations. An alternative approach may be muscle strengthening interventions that have known impacts on gait changes. However, limited studies have examined the quantitative relationships between muscle strengthening and gait. Here, we combine a rapid MRI protocol with wearable sensors to determine that a 12-week exercise intervention induced significant changes in both quadricep muscle morphology and gait kinematics. Morphological changes in different muscles were related to different kinematic changes, which may inform future strengthening interventions that aim to achieve specific changes in gait kinematics.

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