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Abstract #1139

Skeletal muscle energetics and function in sickle cell disease murine model: a synergetic effect of hydroxyurea and endurance training?

Constance P Michel1, Laurent A Messonnier2, Benoit Giannesini1, and David Bendahan1
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2Laboratoire Interuniversitaire de Biologie de la Motricité, Chambéry, France


In sickle cell disease (SCD), hydroxyurea can increase foetal haemoglobin production and restore oxygen-carrying capacity of patients. As endurance training is also known to improve muscle aerobic capacity, one can wonder whether hydroxyurea and endurance training can have a synergetic effect. Townes mice (model of SCD) have been trained with and without hydroxyurea for 8 weeks. Muscle energetics and function were assessed in response to a rest-stimulation-recovery protocol before and after interventions. While training increased force production, mitochondrial function was improved when training was combined to hydroxyurea supplementation. In SCD, this combination would have a synergetic effect in muscle energetics.

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