Abstract #1185

Parahydrogen-Induced Polarization Relayed via Proton Exchange: Application to biological molecules.

Kolja Them¹ and Jan Hövener¹

¹Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, Kiel, Germany

Synopsis

Parahydrogen-induced polarization relayed via proton exchange (PHIP-X) is a new method to hyperpolarize a variety of molecules that participate in suitable fast proton exchange with allyl alcohol. The combination of the wide applicability of polarization-transfer via proton exchange and the strong polarization obtained using hydrogenative of PHIP opens up new avenues to hyperpolarize biological molecules such as glucose, lactate and pyruvate. Hence, PHIP-X provides a promisingnew platform for potential applications in metabolic MRI.

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