Parahydrogen-induced polarization relayed via proton exchange (PHIP-X) is a new method to hyperpolarize a variety of molecules that participate in suitable fast proton exchange with allyl alcohol. The combination of the wide applicability of polarization-transfer via proton exchange and the strong polarization obtained using hydrogenative of PHIP opens up new avenues to hyperpolarize biological molecules such as glucose, lactate and pyruvate. Hence, PHIP-X provides a promisingnew platform for potential applications in metabolic MRI.
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