Oxygen Extraction Fraction is higher in elderly participants with a higher cardiovascular disease risk; a combined QSM and ASL study
John McFadden1, Julian Matthews1, Lauren Scott1, Karl Herholz1, Ben Dickie2,3, Hamied Haroon1, Oliver Sparasci1,4, Saadat Ahmed1, Natalia Kyrtata1,5, Geoffrey JM Parker6,7, Hedley C A Emsley1,8,9, Maélène Lohezic10, and Laura M Parkes1,3
1Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 2Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom, 3Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom, 5University Hospital of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom, 6Centre for Medical Image Computing, University College London, London, United Kingdom, 7Bioxydyn Limited, Manchester, United Kingdom, 8Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, 9Department of Neurology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom, 10GE Healthcare, Manchester, United Kingdom
We investigated quantitative susceptibility mapping (QSM) and arterial spin labelling (ASL) to measure cerebrovascular parameters in elderly people with a range of vascular disease risk (QRisk) and cognitive impairment. Cerebral blood flow (CBF) and arterial transit time (ATT) were derived from ASL and oxygen extraction fraction (OEF) from QSM. Regional estimates were obtained by matching six large veins to their draining territories. QRisk had a significant positive relationship with ATT. OEF had a significant compensatory increase with altered ATT and CBF. Both OEF and ATT were found to be elevated with impaired cognition.
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