Investigation of myelin using T1/T2 ratio imaging across multiple datasets: comparable or not?
Riona Fumi1, Hanna Maksimuk2,3, James H Cole4,5, and Sjoerd B Vos2,4,6
1Queen Square Institute of Neurology, University College London, London, United Kingdom, 2Neuroradiological Academic Unit, Queen Square Institute of Neurology, University College London, London, United Kingdom, 3Department of Radiology, Brest Regional Clinical Hospital, Brest, Belarus, 4Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 5Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom, 6Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia, Perth, Australia
Cortical T1/T2 ratios (T1/T2r) have been used to assess myelination along the lifespan and investigate demyelination in neurological diseases. Creating a comprehensive normative population from open-access datasets could facilitate widespread adoption of this technique. Here we investigate comparability between two such publicly available datasets, OASIS3 and CamCAN. We find that they vary in terms of offset, lifespan trajectory, and presence (OASIS3) or absence (CamCAN) of hemispheric asymmetry. This variability exists despite both studies use the same scanner model, and is likely increased across different scanner models and vendors. These findings indicate that combining data from different studies requires advanced normalisation.
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