Quantifying metabolites in large brain areas by 3D Echo Planar Spectroscopic Imaging spectral averaging for a study of cigarette smoking
Jeffry R Alger1,2,3,4, Maylen Perez Diaz5, Joseph O'Neill5, Dara Ghahremani5, Andy C Dean5, Sulaiman Sheriff6, Andrew A Maudsley6, and Edythe London5
1NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, 2University of California, Los Angeles, Los Angeles, CA, United States, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Hura Imaging Inc, Calabasas, CA, United States, 5Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 6Radiology, University of Miami, Miami, FL, United States
Spectral averaging of thousands of magnetic resonance spectroscopic imaging voxel spectra over large brain volumes provides a means of assessing low-level and/or hard-to-quantify metabolite differences over large brain volumes between groups of individuals.
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