Abstract #1253

Quantifying metabolites in large brain areas by 3D Echo Planar Spectroscopic Imaging spectral averaging for a study of cigarette smoking

Jeffry R Alger^1,2,3,4, Maylen Perez Diaz⁵, Joseph O'Neill⁵, Dara Ghahremani⁵, Andy C Dean⁵, Sulaiman Sheriff⁶, Andrew A Maudsley⁶, and Edythe London⁵

¹NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, ²University of California, Los Angeles, Los Angeles, CA, United States, ³Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Hura Imaging Inc, Calabasas, CA, United States, ⁵Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ⁶Radiology, University of Miami, Miami, FL, United States

Synopsis

Spectral averaging of thousands of magnetic resonance spectroscopic imaging voxel spectra over large brain volumes provides a means of assessing low-level and/or hard-to-quantify metabolite differences over large brain volumes between groups of individuals.

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