High-resolution T1 atlas for subject-specific abnormality detection at 7T
Gian Franco Piredda1,2,3, Piotr Radojewski4,5, Arun Joseph5,6,7, Gabriele Bonanno5,6,7, Karl Egger8, Shan Yang8, Punith B. Venkategowda9, Ricardo A. Corredor-Jerez1,2,3, Bénédicte Maréchal1,2,3, Roland Wiest4,5, Jean-Philippe Thiran2,3, Tom Hilbert1,2,3, and Tobias Kober1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Support Center for Advanced Neuroimaging, Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University, Bern, Switzerland, 5Translational Imaging Center, sitem-insel AG, Bern, Switzerland, 6Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 7Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 8Department of Neuroradiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 9Siemens Healthcare Pvt. Ltd., Bangalore, India
Previous studies at 3T have shown that T1 relaxometry enables personalized characterization of brain tissues by comparing physical properties of a single patient to a normative atlas. Ultra-high field imaging allows exploiting this concept at even higher resolutions, which can be crucial to detect certain diseases. To this end, here we established an atlas of normative T1 values at 7T from acquisitions with 0.6$$$\times$$$0.6$$$\times$$$0.6 mm3 isotropic resolution. Additionally, the clinical potential and improvement of 7T vs. 3T imaging is shown in two case reports from patients scanned at both field strengths.
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