Correction of CSF Partial Volume Bias in 23Na Magnetic Resonance Fingerprinting
Fabian J Kratzer1, Sebastian Flassbeck1,2,3, Sebastian Schmitter1,4, Tobias Wilferth5, Peter Bachert1, Mark E Ladd1, and Armin M Nagel1,5
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Center for Biomedical Imaging, New York University, New York, NY, United States, 3Center for Advanced Imaging Innovation and Research, New York University, New York, NY, United States, 4Physikalisch Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 5Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg (FAU), Erlangen, Germany
This work investigates the bias in the quantified relaxation times due to partial volume contributions of CSF for 23Na magnetic resonance fingerprinting (MRF) and reference methods. In simulations, a CSF contribution of only 10% resulted in an overestimation of 17% (31%) in T2l* in brain tissue for MRF (the reference). Further, a simple approach for CSF bias correction for 23Na MRF is proposed. This reduced the average absolute T1 deviation in brain tissue from 15% to 4%. The deviation in T2l* (T2s*) was reduced from 17% (35%) to 9% (5%). Finally, the correction was applied to in vivo MRF data.
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