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Abstract #1320

Combined T2*-diffusion imaging of the fetal lungs in normal and preterm fetuses

Carla Lily Avena-Zampieri1,2, Lisa Story1,2, Daniel Cromb1, Mary Rutherford1, Alena Uus3, Paddy Slator4, and Jana Hutter1,3
1Perinatal Health and Imaging, Kings College London, London, United Kingdom, 2Women and Children’s Health, Kings College London, London, United Kingdom, 3Department of Biomedical Engineering, Kings College London, London, United Kingdom, 4Centre for Medical Image Computing, UCL, London, United Kingdom


Advanced functional MRI techniques were applied to the fetal lungs to increase our understanding of in-utero lung development, imperative for accurate antenatal diagnosis to identify fetuses at highest risk of morbidity. Our preliminary results show that combined T2*-diffusion imaging is a feasible technique to analyse the developing lungs in utero. A reduction in both lung volumes and T2* values associated with fetuses that subsequently delivered preterm was identified - paving the way for future more detailed in depth studies.

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