Structural and functional brain imaging in a rat model of fetal growth restriction
Yohan van de Looij1,2, Jérôme Mairesse1,3, Julien Pansiot4, Manuela Zinni4, Stéphane V Sizonenko1, and Olivier Baud1,3
1Division of Development and Growth, Department of Paediatrics and Gynaecology-Obstetrics, School of Medicine, University of Geneva, Geneva, Switzerland, 2Center for Biomedical Imaging, Animal Imaging Technology section, Federal Institute of Technology of Lausanne, Lausanne, Switzerland, 3Division of Neonatology and Pediatric Intensive Care, Children's University Hospital of Geneva, Geneva, Switzerland, 4INSERM UMR1141 NeuroDiderot, University Paris Diderot, Sorbonne Paris Cité, Paris, France
Brain injuries and subsequent neurodevelopmental impairments observed following Fetal Growth Restriction (FGR) were shown to be associated with an exacerbated neonatal neuro-inflammation. The aim of this work was to characterize a rat model of FGR by advanced diffusion MRI (DTI and NODDI) and functional ultrasounds (fUS). We show in this study that neonatal inflammation lead to transient microstructural damages and subsequent behavioral and functional disabilities at long term. This model mimics very closely clinical reality in babies born following FGR. Innovative neuroimaging tools associated with this neuro-inflammatory model pave the way for their translational use in human neonates.
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