Brain injuries and subsequent neurodevelopmental impairments observed following Fetal Growth Restriction (FGR) were shown to be associated with an exacerbated neonatal neuro-inflammation. The aim of this work was to characterize a rat model of FGR by advanced diffusion MRI (DTI and NODDI) and functional ultrasounds (fUS). We show in this study that neonatal inflammation lead to transient microstructural damages and subsequent behavioral and functional disabilities at long term. This model mimics very closely clinical reality in babies born following FGR. Innovative neuroimaging tools associated with this neuro-inflammatory model pave the way for their translational use in human neonates.
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