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Abstract #1347

Simultaneous mapping of compartment-specific T2 and T2* with Diffusion-PEPTIDE imaging

Ting Gong1, Merlin J. Fair2, Kawin Setsompop2,3, and Hui Zhang1
1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, CA, United States, 3Department of Electrical Engineering, Stanford University, Stanford, CA, United States


Inspired by recent developments in combined relaxometry-diffusion imaging and growing interests in T2* imaging, this study achieves simultaneous compartmental T2 and T2* mapping for the first time. We take advantage of the recently developed diffusion-PEPTIDE imaging technique, which allows for efficient acquisition of diffusion datasets with varying T2/T2* contrast. A relaxometry-diffusion combined microstructure model and a robust multi-stage fitting approach are developed to enable compartmental T2 and T2* mapping. This technique could be a new tool for future neuroimaging studies benefiting from quantification of T2-T2*-diffusion, such as studying iron content related development and pathology.

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