Simultaneous T1 and T2 mapping with QuantoRAGE: a new MP2RAGE variant using T2-prepared inversion
Gabriele Bonanno1,2,3, José P. Marques4, Tobias Kober5,6,7, and Tom Hilbert5,6,7
1Siemens Healthcare AG, Bern, Switzerland, 2Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 3Translational Imaging Center, sitem-insel, Bern, Switzerland, 4Donders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 7LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
T1 and T2 relaxometry provide important quantitative information and can serve as imaging biomarkers thanks to their sensitivity to pathology. However, quantitative imaging requires long scan times for high-resolution whole-brain coverage. Magnetization-prepared approaches combined with fast sequences allow for high isotropic resolution, but they are often biased due to other relaxation mechanisms than the one being probed. To account for this effect, we introduce QuantoRAGE: a new method that uses a T2-prepared inversion within an accelerated MP2RAGE sequence for simultaneous T1 and T2 mapping. Preliminary tests demonstrate the feasibility to obtain high-resolution simultaneous T1 and T2 relaxometry at 3T.
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