The image qualities of two high-resolution MRI sequences of the neck—CAIPIRINHA-VIBE and GRASP-VIBE—were compared. 173 patients clinically indicated for neck MRI were scanned using both sequences with isotropic (<1 mm) in-plane resolution. The image quality was qualitatively assessed by two radiologists. Quantitative assessments (i.e., non-uniformity, contrast-to-noise ratio and signal-to-noise ratio) were performed in all patients, a phantom and a healthy volunteer. GRASP-VIBE outperformed CAIPIRINHA-VIBE in all qualitative assessments except for the fat suppression degree. Quantitative assessments were significantly superior in GRASP-VIBE than in CAIPIRINHA-VIBE. Therefore, GRASP-VIBE may be a better alternative to CAIPIRINHA-VIBE for head and neck MRI.