Abstract #1435
MRI based Radiomics for Distinguishing IDH-mutant from IDH wild-type Grade-4 Astrocytomas
Seyyed Ali Hosseini1, Isaac Shiri2, Ghasem Hajianfar3, Stephen Bagley4, MacLean Nasrallah5, Donald M O’Rourke 6, Suyash Mohan7, and SANJEEV CHAWLA7
1Medical physics and biomedical engineering, Tehran university of medical science, Karaj, Iran (Islamic Republic of), 2Medical Imaging, University of Geneva, Geneva, Switzerland, 3Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran (Islamic Republic of), 4Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 5Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 6Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 7Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States
Synopsis
To distinguish IDH-mutant from IDH wild-type grade-4 astrocytomas, conventional MR imaging (post-contrast T1-weighted and T2-Flair images) was acquired from 57 patients [IDH-mutant (n=23) and IDH-wild-type (n=34) grade-4 astrocytomas]. Post-contrast T1-weighted and T2-FLAIR images were resliced, resampled and co-registered. Neoplasms were segmented into whole tumor, enhancing region, central necrotic region, edema region, and core tumor (contrast enhancing + necrotic region). A total of 105 first-, second-, higher-order and shape based radiomics features were extracted from each ROI. Readily interpretable and quantitative features from different sub-regions of neoplasms were observed with high diagnostic performances in distinguishing IDH-mutant from IDH wild-type grade-4 astrocytomas.
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