Abstract #1435

MRI based Radiomics for Distinguishing IDH-mutant from IDH wild-type Grade-4 Astrocytomas

Seyyed Ali Hosseini¹, Isaac Shiri², Ghasem Hajianfar³, Stephen Bagley⁴, MacLean Nasrallah⁵, Donald M O’Rourke ⁶, Suyash Mohan⁷, and SANJEEV CHAWLA⁷

¹Medical physics and biomedical engineering, Tehran university of medical science, Karaj, Iran (Islamic Republic of), ²Medical Imaging, University of Geneva, Geneva, Switzerland, ³Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran (Islamic Republic of), ⁴Hematology-Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁵Pathology and Lab Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁶Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁷Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

Synopsis

To distinguish IDH-mutant from IDH wild-type grade-4 astrocytomas, conventional MR imaging (post-contrast T1-weighted and T2-Flair images) was acquired from 57 patients [IDH-mutant (n=23) and IDH-wild-type (n=34) grade-4 astrocytomas]. Post-contrast T1-weighted and T2-FLAIR images were resliced, resampled and co-registered. Neoplasms were segmented into whole tumor, enhancing region, central necrotic region, edema region, and core tumor (contrast enhancing + necrotic region). A total of 105 first-, second-, higher-order and shape based radiomics features were extracted from each ROI. Readily interpretable and quantitative features from different sub-regions of neoplasms were observed with high diagnostic performances in distinguishing IDH-mutant from IDH wild-type grade-4 astrocytomas.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.