Comparison of Physiological Noise Models for Thermal Stimulus fMRI in the Cervical Spinal Cord at 7T
Alan C Seifert1,2,3 and S Johanna Vannesjo4
1Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
A physiological noise model (PNM) is crucial for maximizing sensitivity and specificity to activation in 7T spinal cord fMRI. The PNM must balance exhaustive modeling of non-BOLD signal, preservation of degrees of freedom, and avoidance of nuisance regressors that may be correlated with the task. We compared four candidate PNMs. A 37-term PNM and a 35-term PNM excluding heart rate and respiratory volume per unit time, which may be correlated with the task, performed approximately equally well. A 32-term PNM containing only regressors derived from physiological recordings, and a 3-term PNM containing only image-derived regressors, were also evaluated.
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