A physiological noise model (PNM) is crucial for maximizing sensitivity and specificity to activation in 7T spinal cord fMRI. The PNM must balance exhaustive modeling of non-BOLD signal, preservation of degrees of freedom, and avoidance of nuisance regressors that may be correlated with the task. We compared four candidate PNMs. A 37-term PNM and a 35-term PNM excluding heart rate and respiratory volume per unit time, which may be correlated with the task, performed approximately equally well. A 32-term PNM containing only regressors derived from physiological recordings, and a 3-term PNM containing only image-derived regressors, were also evaluated.
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