Abstract #1509

Characterization of relationship between MR microstructural parameters and memory in older subjects

Scott Peltier^1,2, Michelle Karker¹, Jon-Fredrik Nielsen^1,2, Navid Seraji-Bozorgzad³, Henry Paulson³, Bruno Giordani^3,4, and Benjamin M. Hampstead^4,5

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Functional MRI Laboratory, University of Michigan, Ann Arbor, MI, United States, ³Neurology, University of Michigan, Ann Arbor, MI, United States, ⁴Psychiatry, University of Michigan, Ann Arbor, MI, United States, ⁵Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, United States

Synopsis

This work examined the relationship between white matter microstructure parameters calculated by NODDI and a composite measure of memory function. Connectome predictive modeling was done on fractional anisotropy, orientation dispersion, and neurite density maps. Significant relationships were found for all parameters, with orientation dispersion having the highest correlation between predicted and observed memory scores.

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