Abstract #1534

Iron Imaging with 3D Multi-Gradient Recalled Echo (3D-mGRE) and 3D Ultra-short Echo (3D-UTE) Sequences: A Phantom Comparison Study

Humberto Monsivais¹, Xin Shen², Antonia Susnjar², Ali Caglar Özen³, Serhat Ilbey ³, Mark Chiew ⁴, Aparna Karnik⁵, Uzay Emir^1,2, and Ulrike Dydak^1,6

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³Department of Radiology, Medical Physics, University of Freiburg, Freiburg, Germany, ⁴Wellcome Centre for Integrative Neuroimaging, University of Oxford, England, United Kingdom, ⁵Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ⁶Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

This phantom study aimed to compare a conventional multi-gradient recalled echo (mGRE) sequence and an ultra-short echo (UTE) with a novel 3D rosette k-space trajectory for iron (Fe) detection and quantification. Conventional mGRE imaging may underestimate massive Fe load due to the long echo times (TEs). Advanced UTE techniques with TEs 10-200 times shorter than conventional mGRE sequences can capture fast signal decay caused by high Fe content. Our preliminary results show that both sequences yield a strong linear relationship between R2* values and Fe concentrations, with the 3D-UTE results aligning more with expected R2* values for high Fe concentrations.

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