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Abstract #1534

Iron Imaging with 3D Multi-Gradient Recalled Echo (3D-mGRE) and 3D Ultra-short Echo (3D-UTE) Sequences: A Phantom Comparison Study

Humberto Monsivais1, Xin Shen2, Antonia Susnjar2, Ali Caglar Özen3, Serhat Ilbey 3, Mark Chiew 4, Aparna Karnik5, Uzay Emir1,2, and Ulrike Dydak1,6
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Department of Radiology, Medical Physics, University of Freiburg, Freiburg, Germany, 4Wellcome Centre for Integrative Neuroimaging, University of Oxford, England, United Kingdom, 5Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 6Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States


This phantom study aimed to compare a conventional multi-gradient recalled echo (mGRE) sequence and an ultra-short echo (UTE) with a novel 3D rosette k-space trajectory for iron (Fe) detection and quantification. Conventional mGRE imaging may underestimate massive Fe load due to the long echo times (TEs). Advanced UTE techniques with TEs 10-200 times shorter than conventional mGRE sequences can capture fast signal decay caused by high Fe content. Our preliminary results show that both sequences yield a strong linear relationship between R2* values and Fe concentrations, with the 3D-UTE results aligning more with expected R2* values for high Fe concentrations.

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