Abstract #1536
Human brain POCE MRS at 7T using a 13C birdcage coil and 8 transmit-receive 1H antennas with a 32-channel 1H receive array
Sarah M Jacobs1, Jeanine J Prompers1, Wybe JM van der Kemp1, Tijl A van der Velden1, Mark WJM Gosselink1, Ettore F Meliadò1, Hans M Hoogduin1, Graeme F Mason2, Robin A de Graaf2,3, Anja G van der Kolk1,4, Cezar Alborahal1, Dennis W Klomp1, and Evita C Wiegers1
1Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, United States, 4Department of Radiology, Radboud University Medical Center, Nijmegen, Netherlands
Synopsis
We have shown that it is feasible to perform POCE MRS in the human brain at 7T during a uniformly labeled [U-13C] glucose infusion in three healthy volunteers, using a 13C birdcage head coil combined with 8 transmit-receive 1H antennas with a 32-channel 1H receive array. STEAM-POCE and sLASER-POCE provided similar sensitivity for the [4-13C]-Glx-H4 signals. POCE examinations could be performed in two locations, i.e. the frontal and occipital lobe, in one session, allowing them to be easily merged with 1H MRI.
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