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Abstract #1546

Striatal tau deposition in mild cognitive impairment revealed by removal of iron-related off-target binding effects in 18F-AV1451 PET

Jason Langley1, Sumanth Dara2, Ilana Bennett3, and Xiaoping Hu1,2
1Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, 2Department of Bioengineering, University of California Riverside, Riverside, CA, United States, 3Department of Psychology, University of California Riverside, Riverside, CA, United States

Synopsis

We use tissue susceptibility to control for iron-related off-target binding effects in 18F-AV1451 PET and examine the impact of APOE-ε4 carrier status on striatal tau-PET signal in mild cognitive impairment. We found significant increases in tau-PET SUVR in the putamen (p=0.01) and caudate nucleus (p=0.046) of APOE-ε4 positive participants compared to APOE-ε4 negative participants. Controlling for striatal iron, significant correlations were seen between striatal tau-PET SUVR memory measures in the control (putamen: r=0.435; caudate: r=0.623) and APOE-ε4 positive MCI (putamen: r=0.403; caudate: r=0.648) groups with greater tau burden correlated with greater memory impairment.

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