Abstract #1567

5D Free-Running-LIBRE MRI for 3D whole-heart Cine: A pilot study in patients at 3T

Katerina Eyre¹, Michael Chetrit¹, Lisa Leroi², Jérôme Yerly^3,4, Mitchel Benovoy², Davide Piccini^3,5, Matthias Stuber^3,4, Matthias Friedrich^1,2,6,7,8, and Jessica AM Bastiaansen^3,9,10

¹Radiology, McGill University Health Centre (MUHC), Montreal, QC, Canada, ²Circle Cardiovascular Imaging Inc., Calgary, AB, Canada, ³Diagnostic and Interventional Radiology, Le Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁴Center for BioMedical Imaging (CIBM), Lausanne, Switzerland, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶Radiology, Université de Montréal, Montreal, QC, Canada, ⁷Cardiac Sciences, University of Calgary, Calgary, AB, Canada, ⁸Heidelberg University, Heidelberg, Germany, ⁹Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, Bern, Switzerland, ¹⁰Translational Imaging Cente, Bern, Switzerland

Synopsis

Cardiac magnetic resonance imaging is often limited by long scan times and the need for multiple breath holds. A Free-Running sequence may overcome this limitation by providing 3-D cine data in a free-breathing non-ECG-triggered acquisition of 7 minutes. The clinical applicability of this method was tested in a cohort of 9 patients with varying pathologies. Myocardial blood-pool volumes and ejection fractions were compared between standard 2-D protocols and 5-D Free-Running-LIBRE. Free-Running-LIBRE successfully quantified volumes and ejection fractions with results correlating strongly to reference measurements. The method demonstrated additional potential to visualize irreversible myocardial injury in these patients.

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