5D Free-Running-LIBRE MRI for 3D whole-heart Cine: A pilot study in patients at 3T
Katerina Eyre1, Michael Chetrit1, Lisa Leroi2, Jérôme Yerly3,4, Mitchel Benovoy2, Davide Piccini3,5, Matthias Stuber3,4, Matthias Friedrich1,2,6,7,8, and Jessica AM Bastiaansen3,9,10
1Radiology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 2Circle Cardiovascular Imaging Inc., Calgary, AB, Canada, 3Diagnostic and Interventional Radiology, Le Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 4Center for BioMedical Imaging (CIBM), Lausanne, Switzerland, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Radiology, Université de Montréal, Montreal, QC, Canada, 7Cardiac Sciences, University of Calgary, Calgary, AB, Canada, 8Heidelberg University, Heidelberg, Germany, 9Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, Bern, Switzerland, 10Translational Imaging Cente, Bern, Switzerland
Cardiac magnetic resonance imaging is often limited by long scan times and the need for multiple breath holds. A Free-Running sequence may overcome this limitation by providing 3-D cine data in a free-breathing non-ECG-triggered acquisition of 7 minutes. The clinical applicability of this method was tested in a cohort of 9 patients with varying pathologies. Myocardial blood-pool volumes and ejection fractions were compared between standard 2-D protocols and 5-D Free-Running-LIBRE. Free-Running-LIBRE successfully quantified volumes and ejection fractions with results correlating strongly to reference measurements. The method demonstrated additional potential to visualize irreversible myocardial injury in these patients.
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