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Abstract #1575

Reproducibility of Left Ventricular CINE DENSE Strain in Pediatric Subjects with Duchenne Muscular Dystrophy

Zhan-Qiu Liu1,2, Nyasha Maforo3, Pierangelo Renella3, Nancy Halnon3, Holden Wu3, and Daniel Ennis4
1Cardiovascular Institute, Stanford University, Mountain View, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3University of California, Los Angeles, Los Angeles, CA, United States, 4Stanford University, Mountain View, CA, United States


Left ventricular (LV) peak mid-wall circumferential strain (Ecc) and twist are early biomarkers for evaluating the subtle and highly variable onset and progression of cardiomyopathy in pediatric subjects with Duchenne muscular dystrophy (DMD). Cine Displacement Encoding with Stimulated Echoes (DENSE) has proven sensitive to changes in Ecc and twist, but has not been reported in a DMD cohort. We show that free-breathing DENSE CMR at 3T provides highly reproducible middle-ventricular Ecc, radial strain (Err), and twist measurements in healthy boys and boys with DMD without evidence of late gadolinium enhancement.

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