Abstract #1575

Reproducibility of Left Ventricular CINE DENSE Strain in Pediatric Subjects with Duchenne Muscular Dystrophy

Zhan-Qiu Liu^1,2, Nyasha Maforo³, Pierangelo Renella³, Nancy Halnon³, Holden Wu³, and Daniel Ennis⁴

¹Cardiovascular Institute, Stanford University, Mountain View, CA, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States, ³University of California, Los Angeles, Los Angeles, CA, United States, ⁴Stanford University, Mountain View, CA, United States

Synopsis

Left ventricular (LV) peak mid-wall circumferential strain (E_cc) and twist are early biomarkers for evaluating the subtle and highly variable onset and progression of cardiomyopathy in pediatric subjects with Duchenne muscular dystrophy (DMD). Cine Displacement Encoding with Stimulated Echoes (DENSE) has proven sensitive to changes in E_cc and twist, but has not been reported in a DMD cohort. We show that free-breathing DENSE CMR at 3T provides highly reproducible middle-ventricular E_cc, radial strain (E_rr), and twist measurements in healthy boys and boys with DMD without evidence of late gadolinium enhancement.

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