Hybrid PET/MRI is a promising tool that can characterize both metabolic and structural information and has been used extensively in the context of MI-related heart failure. We propose a novel dual-condition protocol that can be used to characterize metabolic state of cardiac tissue in vivo following MI, under different substrate conditions. Our results show significant metabolic changes under fasting and glucose loading conditions, and further longitudinal differences in MI-related metabolic remodeling within both the infarct zone and surrounding myocardium. This framework has potential to be used in testing therapeutic efficacy following MI in both preclinical and clinical contexts.
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