Inter-scanner variability can reduce the statistical power of neuroimaging studies due to the increased variance in the data. While existing efforts employ consistent high level parameters to acquire data across scanners, we hypothesize that differences due to sequence implementation and reconstruction algorithms contribute substantially to variability in multi-center settings. We propose a unified vendor-neutral MP-RAGE protocol based on the Pulseq sequence development platform that can be used consistently across sites and vendors for reducing inter-scanner variability. Preliminary results show increased consistency of cortical thickness across sites using Pulseq protocol compared to vendor-provided sequences.
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