Abstract #1636

MRSI DETECTABLE CHOLINE METABOLISM AS MARKER FOR GENDER DIFFERENCES IN AGING

Ulrich Pilatus¹, Gunter P. Eckert², Nasir Ludin¹, Silke Matura¹, Johannes Pantel¹, Carmen Silaidos², Lena Wachter², and Elke Hattingen¹

¹Goethe-University Frankfurt, Frankfurt, Germany, ²Justus-Liebig-University of Giessen, Giessen, Germany

Synopsis

Combining quantitative (mmol/l) ¹H MRSI and ³¹P MRSI data from the brain of healthy volunteers revealed a choline component (rCho=tCho-(PCho+GPC)) which is visible with ¹H MRSI but missing in ³¹P MRSI. This component, which may account for a fraction of mobile phospholipids, is reduced in young female (mean age 26) subjects. Lower levels would indicate a higher integrity of the membrane phospholipids in the brain of young women. A possible reason is the higher estrogen levels in this group.

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