Abstract #1640

In vivo myelin water imaging at 0.55T

Jessica Schäper^1,2 and Oliver Bieri^1,2

¹Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ²Division of Radioligical Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland

Synopsis

Myelin water fraction (MWF) imaging is an important tool to investigate demyelination in WM. When using GRE sequences, the method suffers from T₂* effects, leading to a non-exponential behaviour. This can potentially influence the calculation of MWF. At low fields susceptibility effects are less and the assumption of biexponential T₂-decay is more accurate. Here, the feasibility of MWF at 0.55 T, using biexponential fitting was demonstrated.

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