A new straight forward approach for rapid and robust quantification of myocardial circumferential strain has been developed. The key to this method is placement of the linear tags in 60-degree pattern offsets and alignment of the tags with the AHA segments for optimized segmental analysis. The approach has been implemented for the first time for evaluation of the human cardiomyocyte transplantation benefits in the infarcted pig heart. We have shown the temporal changes in circumferential strain and strain rate of the infarcted segments of myocardium and recovery of myocardial strain followed human cardiomyocyte transplantation in comparison with untreated control group.
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