Diffusion tensor cardiovascular magnetic resonance (DT-CMR) has proved to be a unique non-invasive method to investigate the myocardial microstructure. The time dependence of the diffusion tensor provides insights into the barriers that restrict free diffusion. We present a method to assess the time dependence of diffusion in the beating heart along with numerical simulations that demonstrate the sensitivity of this potential new biomarker to changes in myocardial microstructure including membrane permeability, extracellular volume fraction and cell hypertrophy.
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