Abstract #1722
Inter-scanner reproducibility and variability assessment of advanced liver diffusion MRI metrics
Francesco Grussu1, Kinga Bernatowicz1, Ignasi Barba2, Marco Palombo3, Juan Francisco Corral4,5, Marta Vidorreta6, Xavier Merino4,5, Richard Mast4,5, Núria Roson4,5, Nahúm Calvo‐Malvar4,7, Manuel Escobar Amores4,5, Josep R. Garcia-Bennett7, and Raquel Perez-Lopez1,5
1Radiomics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 2NMR Lab, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, 3Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 4Institut de Diagnòstic per la Imatge (IDI), Catalonia, Spain, 5Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 6Siemens Healthineers, Madrid, Spain, 7Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain
Synopsis
Innovative liver Diffusion-Weighted (DW) MRI aims to increase sensitivity and biological specificity of routine DW imaging, but may feature lower reproducibility due to longer scan times and acquisition of highly DW images. We assess inter-scanner reproducibility and variability of metrics from two novel approaches, T2-Intra-Voxel Incoherent Motion-Kurtosis (T2-IVIM-Kurtosis) and Diffusion-Relaxation Hepatic Imaging via Generalised Assessment of DiffusiOn Simulations (DR-HIGADOS), in two 1.5T scanners (Siemens Avanto; Philips Ingenia). Both methods are reproducible across scanners. Cellularity, intra-cellular diffusivity and vascular fraction show the highest measurement variability, implying that larger cohorts may be required in studies that focus on these indices.
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