Abstract #1722

Inter-scanner reproducibility and variability assessment of advanced liver diffusion MRI metrics

Francesco Grussu¹, Kinga Bernatowicz¹, Ignasi Barba², Marco Palombo³, Juan Francisco Corral^4,5, Marta Vidorreta⁶, Xavier Merino^4,5, Richard Mast^4,5, Núria Roson^4,5, Nahúm Calvo‐Malvar^4,7, Manuel Escobar Amores^4,5, Josep R. Garcia-Bennett⁷, and Raquel Perez-Lopez^1,5

¹Radiomics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, ²NMR Lab, Vall d'Hebron Institute of Oncology, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, ³Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, ⁴Institut de Diagnòstic per la Imatge (IDI), Catalonia, Spain, ⁵Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁶Siemens Healthineers, Madrid, Spain, ⁷Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain

Synopsis

Innovative liver Diffusion-Weighted (DW) MRI aims to increase sensitivity and biological specificity of routine DW imaging, but may feature lower reproducibility due to longer scan times and acquisition of highly DW images. We assess inter-scanner reproducibility and variability of metrics from two novel approaches, T2-Intra-Voxel Incoherent Motion-Kurtosis (T2-IVIM-Kurtosis) and Diffusion-Relaxation Hepatic Imaging via Generalised Assessment of DiffusiOn Simulations (DR-HIGADOS), in two 1.5T scanners (Siemens Avanto; Philips Ingenia). Both methods are reproducible across scanners. Cellularity, intra-cellular diffusivity and vascular fraction show the highest measurement variability, implying that larger cohorts may be required in studies that focus on these indices.

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