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Abstract #1731

How does language fMRI activation in tumour patients compare to healthy volunteers?

Rachael Franklin1,2, Enrico de Vita2, Irène Brumer3, Jozef Jarosz1, and Marco Borri1
1Neuroradiology, King's College Hospital, London, United Kingdom, 2School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 3Computer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany


Task-based language fMRI datasets from healthy volunteers (15) and tumour patients (4 with lesions near Wernicke’s area, 6 with lesions near Broca’s area) were compared, to assess the similarity of activation location and extent. Expected areas of the language network were consistently localised in both patients and volunteers. Although patients showed more variation in the extent and strength of activation, our activation metrics for the full patient cohort show similar amount of overlap compared to a size-matched group of volunteers. Furthermore, patient with lesions near Broca’s area had highly consistent activation in specific locations.

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