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Abstract #1737

In vivo direct imaging of visually evoked neuronal responses at milliseconds temporal resolution

Phan Tan Toi1,2, Jun-Ho Kim1, Jang Woo Park3, and Jang-Yeon Park1,2
1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 2Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, 3Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, Korea, Republic of


There has been a long-standing demand for high temporospatial resolution in non-invasive neuroimaging. Using our previously proposed approach for direct imaging of neuronal activity (DIANA-fMRI) with a high temporal resolution of milliseconds, we continued to demonstrate DIANA-fMRI performance in mice in vivo at 9.4T using visual stimulation. The DIANA signal change was significantly increased (~0.2-0.4%) in response to flashing light stimulus, and it was found that DIANA responses of sSC, V1, and V2 were sequentially activated in that order. The DIANA response times of sSC, V1, and V2 were consistent with previous electrophysiological studies.

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