Abstract #1741

Metabolic Changes Immediately Following Sequential Motor Learning: an MRS-fMRI Study

Yasmin Geiger¹, Tali Weiss², Osnat Volovick¹, Inbar Aharon¹, Rinatia Maaravi-Hesseg³, and Avi Karni³

¹Weizmann Institute of Science, Rehovot, Israel, ²Weizmann institute of Science, Rehovot, Israel, ³University of Hifa, Hifa, Israel

Synopsis

Sequential finger tapping (SFT) is a model for motor learning. The initial phase of SFT manifests in changes to behavior, neuronal activation (BOLD) and metabolic concentrations. The metabolic changes and correlations to BOLD and behavioral changes during SFT are still poorly understood. Here we analyze these bilateral changes at the motor cortex using BOLD‑fMRI and ¹H-MRS. We show a significant hemispheric‑dependent correlation between changes in GABA+ and behavior, which do not correlate with the BOLD signal. Additionally, GABA+ basal levels differ between hemispheres.

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