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Abstract #1741

Metabolic Changes Immediately Following Sequential Motor Learning: an MRS-fMRI Study

Yasmin Geiger1, Tali Weiss2, Osnat Volovick1, Inbar Aharon1, Rinatia Maaravi-Hesseg3, and Avi Karni3
1Weizmann Institute of Science, Rehovot, Israel, 2Weizmann institute of Science, Rehovot, Israel, 3University of Hifa, Hifa, Israel


Sequential finger tapping (SFT) is a model for motor learning. The initial phase of SFT manifests in changes to behavior, neuronal activation (BOLD) and metabolic concentrations. The metabolic changes and correlations to BOLD and behavioral changes during SFT are still poorly understood. Here we analyze these bilateral changes at the motor cortex using BOLD‑fMRI and 1H-MRS. We show a significant hemispheric‑dependent correlation between changes in GABA+ and behavior, which do not correlate with the BOLD signal. Additionally, GABA+ basal levels differ between hemispheres.

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