Abstract #1749

High-Field Magnetic Resonance Microscopy of Aortic Plaques in a Mouse Model

Sean Gullette¹, Stephen Andrews², Courtney Whalen², Floyd J. Mattie², Ximing Ge², Catharine Ross², Rita Castro^2,3,4, and Thomas Neuberger^1,5

¹Huck Institutes of The Life Sciences, The Pennsylvania State University, State College, PA, United States, ²Department of Nutritional Sciences, The Pennsylvania State University, State College, PA, United States, ³Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, Portugal, Lisboa, Portugal, ⁴Department of Pharmaceutical Sciences and Medicines, Universidade de Lisboa, Portugal, Lisboa, Portugal, ⁵Department of Biomedical Engineering, The Pennsylvania State University, State College, PA, United States

Synopsis

Currently, histological methods of plaque analysis in aortas from murine models of atherosclerosis do not allow for a holistic view of the vascular lesions. Using high-field MRI, plaque volume in Apoe^-/- mice can be analyzed, and when compared to traditional histology, has a higher throughput and is non-destructive. Using a 3D gradient echo sequence at 14 tesla, high-resolution images of the aortas were achieved. The images were segmented and quantified providing a 3-dimensional view of plaque distribution and volume. Overall, using a high-field MRI system allowed for a detailed and complete view of vascular components.

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