High-Field Magnetic Resonance Microscopy of Aortic Plaques in a Mouse Model
Sean Gullette1, Stephen Andrews2, Courtney Whalen2, Floyd J. Mattie2, Ximing Ge2, Catharine Ross2, Rita Castro2,3,4, and Thomas Neuberger1,5
1Huck Institutes of The Life Sciences, The Pennsylvania State University, State College, PA, United States, 2Department of Nutritional Sciences, The Pennsylvania State University, State College, PA, United States, 3Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, Portugal, Lisboa, Portugal, 4Department of Pharmaceutical Sciences and Medicines, Universidade de Lisboa, Portugal, Lisboa, Portugal, 5Department of Biomedical Engineering, The Pennsylvania State University, State College, PA, United States
Currently, histological methods of plaque analysis in aortas from murine models of atherosclerosis do not allow for a holistic view of the vascular lesions. Using high-field MRI, plaque volume in Apoe-/- mice can be analyzed, and when compared to traditional histology, has a higher throughput and is non-destructive. Using a 3D gradient echo sequence at 14 tesla, high-resolution images of the aortas were achieved. The images were segmented and quantified providing a 3-dimensional view of plaque distribution and volume. Overall, using a high-field MRI system allowed for a detailed and complete view of vascular components.
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