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Abstract #1753

Intraocular pressure elevation induces vascular and functional brain changes: A relative cerebrovascular reactivity resting-state fMRI Study

Russell W. Chan1,2, Yixi Xue1, Ji Won Bang1, Muneeb A. Faiq1, Thajunnisa A. Sajitha1, Royce P. Lee1, Peiying Liu3, Christopher K. Leung4, Gadi Wollstein1, Joel S. Schuman1, and Kevin C. Chan1,5
1Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States, 2Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 4Department of Ophthalmology, The University of Hong Kong, Hong Kong, Hong Kong, 5Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Recently, we used a novel resting-state fMRI method to map relative cerebrovascular reactivity (rCVR) without gas challenge, and demonstrated decreased rCVR in the visual cortex and increased rCVR in the basal forebrain in glaucoma patients relative to healthy subjects. However, the underlying mechanisms remain unclear. Here, we applied a hydrogel-induced glaucoma mouse model to chronically elevate intraocular pressure, mapped rCVR using resting-state fMRI, and measured optomotor responses. Our results showed similar patterns of rCVR changes along with visual impairments, indicating a role of chronic intraocular pressure elevation on the widespread vascular and functional brain changes in experimental glaucoma.

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