Preclinical studies suggest a role of altered γ-aminobutyric acid (GABA)ergic inhibitory tone in the periaqueductal grey (PAG), a key brain area for descending pain modulation, as mechanism contributing to chronic pain. The present 1H-magnetic resonance spectroscopy study investigated GABA, and glutamate/glutamine, concentrations in the PAG of patients with chronic low back pain (CLBP). Using a point resolved spectroscopy sequence with optimized frequency alignment, adequate spectral quality was achieved and increased GABA concentrations (p=0.027) identified in CLBP patients compared to pain-free controls. This finding supports dysregulations in descending pain modulation as factor contributing to chronic pain in humans.
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