Quantitative analysis of hyperpolarized 129Xe ventilation imaging requires overcoming the ill-posed problem of accurately correcting for bias field. The standard solution of N4ITK bias field correction removes not only bias field, but also physiologic gradients of interest. An alternative approach is applying RF depolarization mapping in a cohort of subjects to construct a bias field template. Here, we compare the effect that these different bias field correction techniques have on the 129Xe MRI ventilation gradients in a cohort of healthy patients (n=18).
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