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Abstract #1804

Evaluating physiological gradients after bias field correction of Hyperpolarized 129Xe Gas Ventilation MRI

Junlan Lu1, Suphachart Leewiwatwong2, David Mummy3, and Bastiaan Driehuys2
1Medical Physics, Duke University, Durham, NC, United States, 2Biomedical Engineering, Duke University, Durham, NC, United States, 3Radiology, Duke University, Durham, NC, United States


Quantitative analysis of hyperpolarized 129Xe ventilation imaging requires overcoming the ill-posed problem of accurately correcting for bias field. The standard solution of N4ITK bias field correction removes not only bias field, but also physiologic gradients of interest. An alternative approach is applying RF depolarization mapping in a cohort of subjects to construct a bias field template. Here, we compare the effect that these different bias field correction techniques have on the 129Xe MRI ventilation gradients in a cohort of healthy patients (n=18).

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