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Abstract #1833

A1-diameter asymmetry of the Circle of Willis induces blood-flow changes directed towards the anterior communicating artery

Rick J. van Tuijl1, Maud E.H. Ophelders1, Ynte M. Ruigrok2, Iris N. Vos1, Irene C. van der Schaaf1, Jaco J.M. Zwanenburg1, and Birgitta K Velthuis1
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology, UMC Utrecht, Utrecht, Netherlands


Asymmetry in diameter of the pre-communicating part (A1-segment) of both anterior cerebral arteries is common and is related to anterior communicating artery aneurysm formation. We used TOF-MRA and 4D phase-contrast 3T-MRI in 122 subjects without intracranial aneurysms, and found that blood-flow asymmetry between A1-segments increased linearly with increasing A1 diameter asymmetry. Asymmetry of >30% in A1-segment diameters resulted in statistical significant blood-flow differences compared to persons with symmetric A1-segments. Whether this >30% A1-diameter asymmetry is a good cut-off to define a risk factor for anterior communicating artery aneurysm formation requires further research.

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