Asymmetry in diameter of the pre-communicating part (A1-segment) of both anterior cerebral arteries is common and is related to anterior communicating artery aneurysm formation. We used TOF-MRA and 4D phase-contrast 3T-MRI in 122 subjects without intracranial aneurysms, and found that blood-flow asymmetry between A1-segments increased linearly with increasing A1 diameter asymmetry. Asymmetry of >30% in A1-segment diameters resulted in statistical significant blood-flow differences compared to persons with symmetric A1-segments. Whether this >30% A1-diameter asymmetry is a good cut-off to define a risk factor for anterior communicating artery aneurysm formation requires further research.
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