Quantifying Cardiac Hypertrophy using Biophysical Models of Diffusion MRI
Mohsen Farzi1, Darryl McClymont2, Hannah Whittington2, Marie-Christine Zdora3, Leah Khazin1, Craig A. Lygate2, Christoph Rau3, Erica Dall’Armellina1, Irvin Teh1, and Jürgen E. Schneider1
1Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom, 2Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 3Diamond Light Source Ltd., Oxfordshire, United Kingdom
Biophysical modelling is a valuable technique for interrogating cardiac microstructure. We utilise a two-compartment model where intra- and extra-cellular space were represented by impermeable cylinders and an oblate diffusion tensor, respectively. Data was acquired ex vivo using a bespoke diffusion scheme with five diffusion times, six b-values and ten directions. Cardiomyocyte radius (r = 7.6 versus 8.9 μm) and volume fraction (ICV = 0.56 versus 0.67) were sensitive markers of cardiomyopathy validated in one healthy and one disease heart with transverse aortic constriction (TAC).
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