Abstract #1852

Identification of a single-dose, dual-echo based CBV threshold for fractional tumor burden mapping in recurrent glioblastoma

Aliya Anil¹, Ashely M Stokes¹, Renee Chao¹, Leland Hu², Lea Alhilali³, John P Karis³, Laura C Bell⁴, and C Chad Quarles¹

¹Division of Neuroimaging Research and Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, ²Mayo Clinic Arizona, Phoenix, AZ, United States, ³Southwest Neuroimaging at Barrow Neurological Institute, Phoeix, AZ, United States, ⁴Genentech, South Francisco, CA, United States

Synopsis

Reliable differentiation of tumor recurrence and treatment effects in glioblastoma patients is still a prevailing challenge. The purpose of this study is to identify the optimal threshold for generating fractional tumor burden (FTB) maps derived from single-dose, dual-echo based standardized relative cerebral blood volume measurements. To establish the threshold, dual-echo data was compared to the well-validated, double-dose single echo standardized FTB map. In summary, with the optimized threshold, the single-dose, dual-echo approach yielded FTB maps that strongly agreed with the reference standard, providing a compelling option for clinical use.

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