Identification of a single-dose, dual-echo based CBV threshold for fractional tumor burden mapping in recurrent glioblastoma
Aliya Anil1, Ashely M Stokes1, Renee Chao1, Leland Hu2, Lea Alhilali3, John P Karis3, Laura C Bell4, and C Chad Quarles1
1Division of Neuroimaging Research and Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic Arizona, Phoenix, AZ, United States, 3Southwest Neuroimaging at Barrow Neurological Institute, Phoeix, AZ, United States, 4Genentech, South Francisco, CA, United States
Reliable differentiation of tumor recurrence and treatment effects in glioblastoma patients is still a prevailing challenge. The purpose of this study is to identify the optimal threshold for generating fractional tumor burden (FTB) maps derived from single-dose, dual-echo based standardized relative cerebral blood volume measurements. To establish the threshold, dual-echo data was compared to the well-validated, double-dose single echo standardized FTB map. In summary, with the optimized threshold, the single-dose, dual-echo approach yielded FTB maps that strongly agreed with the reference standard, providing a compelling option for clinical use.
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