Meeting Banner
Abstract #1862

Practical RF-pulse shape designs to minimize off-resonance artifacts in dissolved-phase hyperpolarized 129Xe MRI

Junlan Lu1, Suphachart Leewiwatwong2, Bastiaan Driehuys2, and John Mugler3
1Medical Physics, Duke University, Durham, NC, United States, 2Biomedical Engineering, Duke University, Durham, NC, United States, 3Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States


Minimizing artifacts in 129Xe gas exchange MRI requires selectively exciting the broad dissolved phase resonances, without exciting the much larger gas phase pool. This requires not only a short, selective pulse, but also overcoming pulse distortions imposed by the RF amplifier. Here, we demonstrate a novel, practical RF pulse based on augmenting the traditional Hanning window pulse with tunable DC bias and sub-lobes in the time-domain. We characterized the performance through simulations, phantom, and in vivo testing and determined that the tunable DC bias parameter creates a robust dissolved-phase excitation while minimizing gas-phase contamination.

This abstract and the presentation materials are available to members only; a login is required.

Join Here